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pentobarbital will minimize the extent or effect of tamoxifen by affecting hepatic enzyme CYP2C9/ten metabolism. Use Warning/Watch.pentobarbital will decrease the level or influence of naloxegol by affecting hepatic/intestinal enzyme CYP3A4 metabolism. Contraindicated. Usage of naloxegol with potent CYP3A4 inducers is not proposedBreastfeeding cons